Endocrine Abstracts

Background: Our bodies function optimally when we align our eating & sleeping patterns with our circadian rhythms, the innate 24-hour cycles that tell our bodies when to wake up, when to eat and when to fall asleep. Chronically disrupting this rhythm by eating late night meals & sleep could be a recipe for Diabetes, CVD, and metabolic trouble.Aim and objective: The aim of this study is to investigate whether there was a relationship between morni...

A 25 year old gentleman was referred to the endocrine clinic for evaluation of abnormal thyroid function tests. He reported symptoms of diffuse abdominal pain associated with loose stool up to six times a day with urgency, frequency and tenesmus. These symptoms had been present since childhood, becoming increasingly troublesome over the preceding two years. He also reported symptoms of tiredness, palpitations and sweating episodes. Thyroid function tests were abnormal. TSH was...

Hyperglycaemia is common in patients (~65%) when they are admitted to hospital with ACS. It is recognised to be one of the important prognostic indicators for all-cause mortality in patients who present with ACS, regardless of pre-existing diabetes1. NICE guidelines recommend to keep blood glucose (BG) levels below 11 mmol/l2 and offer all people with hyperglycaemia after ACS (without known diabetes) for HbA1c 3 check before discharge. We were interested to see whether we foll...

Introduction: Hypogonadism is linked to anaemia, sarcopenia and osteoporosis in men. Whereas secondary hypogonadism (SH) is biochemically indistinguishable from nongonadal illness, primary hypogonadism (PH) can be easily diagnosable by the identification of raised gonadotropins.Case Presentation: A 66-years old male with a background history of type 2 diabetes mellitus, arthritis, and hypertension was referred to the haematology services to investigate h...

Objective: Thyroid dysfunctions have various effects on glucose and lipid metabolism. Adiponectin (ADP) is an adipokine decreased in obesity and insulin resistance. In this study, we aimed to investigate the role for ADP in thyroid dysfunction related changes in glucose and lipid metabolism.Methods: Newly diagnosed overt hypothyroid (n=20) and thyrotoxic (n=23) adult patients with a body mass index (BMI)<30 kg/m2 were include...

BackgroundThe role of endocrine testing in idiopathic gynecomastia is controversial. Previous studies suggested that such testing is rarely productive and best done selectively.ObjectivesA retrospective study was performed to evaluate the usefulness of a routine endocrine testing in patients presenting with gynecomastia.MethodsThe medical records of 71 patients wi...

Case history: We describe a case of 35 year old female who presented with abdominal pain, nausea and lower backache. She was initially treated with Trimethoprim for a urinary tract infection. 5 days later, she re-attended hospital with feeling more unwell, ongoing lower abdominal pain and vomiting. On examination, she was haemodynamically stable. She had suprapubic tenderness on abdominal palpation, and the rest of her systemic examination was normal.Inv...

Aim: Hyperthyroidism can affect pregnancy outcomes based on activity of the disease, ongoing use of anti-thyroid drugs (ATD) and TSH receptor antibody (TRAB) positivity. The aim of our audit was to analyse the outcomes of fetal monitoring in pregnant women with previous or current history of active hyperthyroidismMethods: The data on all patients with hyperthyroidism and pregnancy over 3 years was collected. The local guidelines recommend TRAB check at 2...

Queen’s Medical Centre, Nottingham, United KingdomTyrosinemia type-1 is a rare autosomal recessive disorder. It usually presents in an acute form in early infancy. Rarely, it can also present as a chronic form with gradual onset. The key presenting features are failure to thrive, liver dysfunction and/or Fanconi syndrome. We present a perplexing case of a 2-year-old girl with tyrosinemia type-1, who initially presented with failure to thrive and hypophosphatemic rickets w...

Background: Our bodies function optimally when we align our eating & sleeping patterns with our circadian rhythms, the innate 24-hour cycles that tell our bodies when to wake up, when to eat and when to fall asleep. Chronically disrupting this rhythm by eating late night meals & sleep could be a recipe for Hypertension, CVD, and metabolic trouble.Aim and objective: The aim of this study is to investigate whether there was a relationship between m...